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INOVASI SPRAY GEL KOMBINASI SAMBILOTO, BROTOWALI, KUNYIT, DAN LADA HITAM SEBAGAI ALTERNATIF NON-STEROID UNTUK PEMULIHAN EKSIM TOPICAL STEROID WITHDRAWAL
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ABSTRACT
synergistically for the treatment of Topical Steroid Withdrawal by inhibiting the main inflammatory pathways (TNF-α and IL-6, IL-17, NF-κB, and MAPK pathways). The objective of this study was to determine the optimal formulation of a spray gel containing extracts of sambiloto, brotowali, turmeric, and black pepper based on physical characteristics (organoleptic properties, pH, and viscosity). The optimal formulation was analysed using Design Expert software version 13 and the Mixture D-Optimal method. The independent variables in this study were brotowali extract, sambiloto extract, and turmeric extract. The dependent variables were black pepper extract 1%, carbopol 0.5%, TEA 1%, citric acid 1%, ethanol 15%, phenoxyethanol 0.5%, and propylene glycol 5%. The results obtained indicate that the optimal formulation is based on the highest desirability value from the analysis using the Design Expert program, which is 0.867. The optimal formulation for the spray gel formulation is 3% brotowali extract, 4% sambiloto extract, and 3% turmeric extract.
ABSTRAK
Sambiloto, Brotowali, Kunyit, Dan Lada Hitam merupakan tanaman yang bekerja sinergis untuk pengobatan Topical Steroid Withdrawal dengan aktivitas menekan jalur-jalur inflamasi utama ( jalur TNF-α dan IL-6, IL-17, NF-κB, dan MAPK). Tujuan penelitian ini adalah untuk menentukan formula optimal sediaan spray gel yang mengandung ekstrak sambiloto, brotowali, kunyit, dan lada Hitam berdasarkan karakteristik fisik (organoleptis, pH dan viskositas). Formula optimal dianalisis menggunakan perangkat lunak Design Expert versi 13 dan melalui metode Mixture D-Optimal. Variabel independen dalam penelitian ini adalah ekstrak brotowali, ekstrak sambiloto dan ekstrak kunyit. Variabel dependen adalah ekstrak lada hitam 1%, carbopol 0,5%, TEA 1%, Asam sitrat 1%, Etanol 15%, Fenoksietanol 0,5% dan Propilenglikol 5%. Hasil yang diperoleh menunjukkan bahwa formulasi optimal didasarkan pada nilai keinginan tertinggi dari hasil analisis menggunakan program Design Expert sebesar 0,867. Formulasi optimal untuk sediaan spray gel adalah ekstrak brotowali 3%, ekstrak sambiloto 4% dan ekstrak kunyit 3%.
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Adiguna, S. P., Panggabean, J. A., Swasono, R. T., Rahmawati, S. I., Izzati, F., Bayu, A., Putra, M. Y., Formisano, C., & Giuseppina, C. (2023). Evaluations of Andrographolide-Rich Fractions of Andrographis paniculata with Enhanced Potential Antioxidant, Anticancer, Antihypertensive, and Anti-Inflammatory Activities. Plants, 12(6). https://doi.org/10.3390/plants12061220
Anonim. (2017). Farmakope Herbal Indonesia (II). Kementerian Kesehatan Republik Indonesia.
Aprillia, P., Nur, C. I., & Safitri, H. (2020). Uji Aktivitas Antidiabetes Kombinasi Ekstrak Herba Sambiloto Dan Daun Sirih Hijau Pada Mencit. Seminar Nasional Pendidikan Biologi Dan Saintek (SNPBS) Ke-V, 553–561.
Chakraborty, A., Sahoo, M., Roy, S. D., & Dasgupta, R. K. (2018). Anti-Ageing Natural Herbs: a Systemic Review. Indian Research Journal of Pharmacy and Science, 5(3), 1589–1598. https://doi.org/10.21276/irjps.2018.5.3.4
Nuoshi Chena, D. L. Z. H. Y. Z. Y. L. S. W. F. 5 H. L. J. H. D. (2025). Tinospora crispa (L.) Hook.f. & Thomson vines ameliorates hyperuricemia by inhibiting 2 synthesis and promoting excretion of uric acid through targeting NLRP3/caspase-1/IL-1β 3 pathway. Journal of Ethnopharmacology, 340, 119–271.
Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., & Chung, J. H. (2009). Dietary aloe vera supplementation improves facial wrinkles and elasticity and it increases the type i procollagen gene expression in human skin in vivo. Annals of Dermatology, 21(1), 6–11. https://doi.org/10.5021/ad.2009.21.1.6
Dewi, B. S., & Surini, S. (2024). Study on hydrogel eye mask with Centella asiatica L and Aloe vera L extract. Journal of Advanced Pharmacy Education and Research, 14(2), 27–34. https://doi.org/10.51847/9UToWXppYP
Hajar, T., Leshem, Y. A., Hanifin, J. M., Nedorost, S. T., Lio, P. A., Paller, A. S., Block, J., & Simpson, E. L. (2015). A systematic review of topical corticosteroid withdrawal (“steroid addiction”) in patients with atopic dermatitis and other dermatoses. In Journal of the American Academy of Dermatology (Vol. 72, Issue 3, pp. 541-549.e2). Mosby Inc. https://doi.org/10.1016/j.jaad.2014.11.024
Halim, K., & Gunawan, S. (2024). Corticophobia Pada Pasien Psoriasis Di Indonesia: Studi Berbasis Topicop. Damianus Journal of Medicine, 23(3), 206.
Junaid R. Shaikh1, M. K. P. (2019). Recent Advances in Pharmacology of Piper nigrum and Piperine : A Review. International Journal of Innovative Science Engineering and Technology (IJISET), 43–54. https://www.researchgate.net/publication/344538854
Kresnawati, Y., Fitrianingsih, S., Puji Purwaningsih, C., Farmasi, F., & Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang, S. (2022). Formulasi dan Uji Potensi Sediaan Spray Gel Niasiamida Dengan Propilenglikol Sebagai Humektan. Cendekia Journal of Pharmacy, 2(6), 281–290. http://cjp.jurnal.stikescendekiautamakudus.ac.id
Mussard, E., Jousselin, S., Cesaro, A., Legrain, B., Lespessailles, E.,
Esteve, E., Berteina‐raboin, S., & Toumi, H. (2020). Andrographis paniculata and its bioactive diterpenoids against inflammation and oxidative stress in keratinocytes. Antioxidants, 9(6), 1–14. https://doi.org/10.3390/antiox9060530
Rosiana Rizal*1, S. V. M. (2023). Formulasi Sediaan Spray Gel Ekstrak Etanol Pegagan (Centella asiatica (L.) Urban ) Dan Uji Daya Tabir Surya. Journal Sains Farmasi Dan Kesehatan, 1(1), 48–59.
Sari Dewi, B., Meitania Utami, S., Hikmah, F., Werawati, A., & Yulia Nov, L. (2024). Formulasi Sediaan Gel Hand Sanitizer Yang Mengandung Ekstrak Daun Sirih Hijau Dan Ekstrak Daun Kemangi. Prosiding SEMLITMAS: Diseminasi Penelitian Pengabdian Masyarakat, 1(1).
Surya, R., Romulo, A., & Susilo, E. (2021). Optimization of functional beverage formula made from turmeric, tamarind, and ginger by D-optimal mixture design. IOP Conference Series: Earth and Environmental Science, 794(1). https://doi.org/10.1088/1755-1315/794/1/012138
Tripathi, A. K., Ray, A. K., & Mishra, S. K. (2022). Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. In Beni-Suef University Journal of Basic and Applied Sciences (Vol. 11, Issue 1). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1186/s43088-022-00196-1
Vetvicka, V., & Vannucci, L. (2021). Biological properties of andrographolide, an active ingredient of Andrographis Paniculata: a narrative review. Annals of Translational Medicine, 9(14), 1186–1186. https://doi.org/10.21037/atm-20-7830
Werawati, A., Dewi, B. S., Hasanah, U., Aulia, G., Fairuz, A., Tinggi, S., Kesehatan, I., Dharma, W., Tangerang, H., & Pajajaran, J. (2024). Formulasi Dan Uji Aktivitas Antibakteri Sediaan Hidrogel Ekstrak Etanol Daun Kelor. Edu Masda Journal, 08(02).
Widodo, W. T., Karya, S., Bangsa, P., Indonesia, T., Widyarti, S., Sumitro, S. B., & Santjojo, D. H. (2021). In Silico Study of Tyramine-Fe Complex in Brotowali (Tinospora crispa) as Anti-Inflammatory. Proceedings of the 11th Annual International Conference on Industrial Engineering and Operations Management Singapore, 3473–3480.
Wijianto, B., Tendianus, T., & Pratiwi, L. (2024). Use D-Optimal Mixture Design In Formulation Of Onchidiid Slug (Onchidium Typhae) Instant Powder As Functional Foods. Jurnal Farmasi Sains Dan Praktis, 141–149. https://doi.org/10.31603/pharmacy.v10i2.11107
You, J. Q., Liu, Y. N., Zhou, J. S., Sun, X. Y., Lei, C., Mu, Q., Li, J. Y., & Hou, A. J. (2022). cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa. Chinese Journal of Chemistry, 40(24), 2882–2892. https://doi.org/10.1002/cjoc.202200433
Zam Zam, A. N., & Musdalifah, M. (2022). Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator. Journal Syifa Sciences and Clinical Research, 4(2), 304–313. https://doi.org/10.37311/jsscr.v4i2.14146
Zhu, N., Hou, J., & Yang, N. (2021). Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89257-6
DOI: http://dx.doi.org/10.52118/edumasda.v9i2.277
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